Publications

  1. Xia M*, Lu J*, Lan J*, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A†, Zhou X†, Yu X†. (2025). Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 58: 1-14. [PMID: 39644894].

    Previewed by: Yang R, He D. Gut know-how: IL-22 from T cells boosts stress resilience. Immunity 58, 10-12 (2025).

    Highlighted by: Bird L. IL-22 protects against stress-induced anxiety. Nature Reviews Immunology 25, 75 (2025).

  2. Li X*, Yi H*, Jin Z*, Jiang K*, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y†, Yu X†. (2024). MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors. J Exp Med 221(12): e20240959. [PMID: 39545935].

  3. Qi Q*, Zhang H*, Jin Z*, Wang C, Xia M, Chen B, Lv B, Diaz LP, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L†, Schneeberger M†, Yu X†. (2024). Hydrogen Sulfide Produced by the Gut Microbiota Impairs Host Metabolism via Reducing GLP-1 Levels in Male Mice. Nature Metabolism 6(8):1601-1615. [PMID: 39030389].

    Previewed by: Zhao N, Wu G, Zhao L. H(2)S as a metabolic saboteur. Nature Metabolism 6, 1431-1432 (2024).

    Highlighted by: Carty S. Microbial hydrogen sulfide hampers L-cell GLP-1 production. Nature Reviews Endocrinology 20, 570 (2024).

  4. Xie L*, Li C*, Wang C*, Wu Z*, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X†, Yu W†. (2024). Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. Advanced Science (Weinh) 11: e2306378. [PMID:38482749].

  5. Hu W†, Yu X†. (2024). GOSpel for tiny allies. Cell Host and Microbe 32: 450-452. (preview)  [PMID: 38604124].

  6. Lu J*, Lu G*, Tan S*, Xia J*, Xiong H*, Yu X*, Qi Q, Yu X, Li L, Yu H, Xia N, Zhang T, Xu Y†, Lin J†. (2020). A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice. Cell Research 30:936-939. [PMID: 32801356].

Previous research

  1. Yu X* †, Wang Y*, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV. (2014). The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife 3: e04406. [PMID: 25310240].

  2. Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV. (2013). TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science 342: 727-730. [PMID: 24202171].

    Highlighted by: Bordon Y. NFIL3 clocks out TH17 cells. Nature Reviews Immunology 13, 848-848 (2013).

  3. Yu X*, Li L*, Zola J, Aluru M, Ye H, Foudree A, Guo H, Anderson S, Aluru S, Liu P, Rodermel S, Yin Y. (2011). A brassinosteroid transcriptional network revealed by genome-wide identification of BES1 target genes in Arabidopsis thaliana. Plant Journal 65: 634-646. [PMID: 21214652].

  4. Yu X, Li L, Guo M, Chory J, Yin, Y. (2008). Modulation of brassinosteroid-regulated gene expression by Jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis. Proc Natl Acad Sci U S A 105: 7618-7623. [PMID: 18467490].

Collaborative research

  1. Unda SR, Pomeranz LE*, Marongiu R*, Yu X*, Kelly L, Hassanzadeh G, Molina H, Vaisey G, Wang P, Dyke JP, Fung EK, Grosenick L, Zirkel R, Antoniazzi AM, Norman S, Liston CM, Schaffer C, Nishimura N, Stanley SA†, Friedman JM†, Kaplitt MG†. (2024). Bidirectional regulation of motor circuits using magnetogenetic gene therapy. Science Advances 10(41): eadp9150. [PMID: 39383230].

  2. Chen B*†, Yu X, Horvath-Diano C, Ortuño MJ, Tschöp MH, Jastreboff AM, Schneeberger M†. (2024).  GLP-1 programs the neurovascular landscape. Cell Metabolism 36(10): 2173-2189. (review) [PMID: 39357509].

  3. Geng L*, Gao W*, Saiyin H, Li Y, Zeng Y, Zhang Z, Li X, Liu Z, Gao Q, An P, Jiang N, Yu X, Chen X, Li S, Chen L, Lu B, Li A, Chen G, Shen Y, Zhang H, Tian M, Zhang Z†, Li J†. (2023). MLKL deficiency alleviates neuroinflammation and motor deficits in the alpha-synuclein transgenic mouse model of Parkinson's disease. Mol Neurodegener 18: 94. [PMID:38041169].

  4. Ilanges A, Shiao R, Shaked J, Luo J-D, Yu X, Friedman JM. (2022) Brainstem ADCYAP1(+) neurons control multiple aspects of sickness behaviour. Nature 609(7928): 761-771. [PMID: 36071158].

  5. Wang P*, Loh KH*†, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman JM†. (2020). A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue. Nature 583(7818): 839-844. [PMID: 32699414].

  6. Schneeberger M*†, Parolari L*, Das Banerjee T, Bhave V, Wang P, Patel B, Topilko T, Wu Z, Choi CHJ, Yu X, Pellegrino K, Engel EA, Cohen P, Renier N, Friedman JM†, Nectow AR†. (2019). Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell 178(3): 672-685. [PMID: 31257028].

  7. Wang Y, Kuang Z, Yu X, Ruhn KA, Kubo M, Hooper LV. (2017). The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. Science 357: 912-916. [PMID: 28860383].

  8. Stanley SA, Kelly L, Latcha KN, Schmidt SF, Yu X, Nectow AR, Sauer J, Dyke JP, Dordick JS, Friedman JM. (2016) Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism. Nature 531: 647-650. [PMID: 27007848].

  9. Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV. (2011). The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine. Science 334: 255-258. [PMID: 21998396].

  10. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. (2011) γδ intraepithelial lymphocytes are essential mediators of host–microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A 108: 8743-8748. [PMID: 21555560].

  11. Guo H, Li L, Ye H, Yu X, Algreen A, Yin, Y. (2009). Three related receptor-like kinases are required for optimal cell elongation in Arabidopsis thaliana. Proc Natl Acad Sci U S A 106: 7648-7653. [PMID: 19383785].

  12. Li L, Yu X, Thompson A, Guo M, Yoshida S, Asami T, Chory J, Yin Y. (2009). Arabidopsis MYB30 is a direct target of BES1 and cooperates with BES1 to regulate brassinosteroid-induced gene expression. Plant Journal 58: 275-286. [PMID: 19170933].

  13. Zhu Y, Zhao HF, Ren GD, Yu XF, Cao SQ, Kuai BK. (2005). Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis. Cell Research 15: 133-140. [PMID: 15740643].